Monitor the patients lung and cardiovascular status closely. Max: 24 mg/day PO. Leuprolide: (Minor) Consider whether the benefits of androgen deprivation therapy (i.e., leuprolide) outweigh the potential risks of QT prolongation in patients receiving short-acting beta-agonists. Beta-agonists may also be associated with adverse cardiovascular effects including QT interval prolongation, usually at higher doses, when associated with hypokalemia, or when used with other drugs known to prolong the QT interval. Beta-agonists may be associated with adverse cardiovascular effects including QT interval prolongation, usually at higher doses and/or when associated with hypokalemia. Beta-blockers will block the pulmonary effects of inhaled beta-agonists, and in some cases may exacerbate bronchospasm in patients with reactive airways. 2 puffs every 4 to 6 hours as needed for bronchospasm. If concurrent therapy is considered essential, ECG monitoring is recommended. Beta-agonists may be associated with adverse cardiovascular effects including QT interval prolongation, usually at higher doses and/or when associated with hypokalemia. Monitor the patients lung and cardiovascular status closely. A preservative free generic alternative to Proventil Nebules® (albuter … Sterile unit dose Foil pouched and embossed vials for easy identification Albuterol sulfate is a bronchodilator, used off label, to treat asthma and cough related to bronchoconstriction. The usual dosage for adults and pediatric patients 12 years of age and older is 2.5 mg of albuterol (one unit-of-use vial) administered 3 to 4 times daily by nebulization. Beta-agonists may be associated with adverse cardiovascular effects including QT interval prolongation, usually at higher doses and/or when associated with hypokalemia. Enflurane: (Minor) Enflurane, like other halogenated anesthetics, can prolong the QT interval. Nebulizer solution: 2.5 mg two or three times/day as needed; 1.25 - 5 mg every 4-8 hours as needed for quick relief. Chlorpheniramine; Pseudoephedrine: (Moderate) Caution and close observation should be used when albuterol is used concurrently with other adrenergic sympathomimetics, administered by any route, to avoid potential for increased cardiovascular effects. Safety and efficacy have not been established. Bendroflumethiazide; Nadolol: (Moderate) Use of a beta-1-selective (cardioselective) beta blocker is recommended whenever possible when this combination of drugs must be used together. Beta-agonists may be associated with adverse cardiovascular effects including QT interval prolongation, usually at higher doses and/or when associated with hypokalemia. Ceritinib: (Minor) Periodically monitor electrolytes and ECGs in patients receiving concomitant treatment with ceritinib and long-acting beta-agonists; an interruption of ceritinib therapy, dose reduction, or discontinuation of therapy may be necessary if QT prolongation occurs. Beta-agonists may be associated with adverse cardiovascular effects including QT interval prolongation, usually at higher doses, when associated with hypokalemia, or when used with other drugs known to prolong the QT interval. Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked questions. Drugs with a possible risk for QT prolongation and torsade de pointes that should be used cautiously and with close monitoring with panobinostat include beta-agonists. Geriatric patients should receive 2 mg PO every 6 to 8 hours initially. Beta-agonists should be administered with caution to patients being treated with drugs known to prolong the QT interval because the action of beta-agonists on the cardiovascular system may be potentiated. Thiazide diuretics: (Minor) Hypokalemia associated with thiazide diuretics can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded. Epinephrine: (Moderate) Caution and close observation should be used when albuterol is used concurrently with other adrenergic sympathomimetics, administered by any route, to avoid potential for increased cardiovascular effects. The albuterol inhalation solution (eg, Accuneb®) should be used with a jet nebulizer that is connected to an air compressor with good air flow. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with chlorpromazine include the beta-agonists. Clomipramine: (Minor) Tricyclic antidepressants (TCAs) share pharmacologic properties similar to the Class IA antiarrhythmic agents and may prolong the QT interval, particularly in overdose or with higher-dose prescription therapy (elevated serum concentrations). Procarbazine: (Major) Procarbazine has MAOI activity and the cardiovascular effects of beta-2 agonists may be potentiated by concomitant use of MAOIs. Beta-blockers will block the pulmonary effects of inhaled beta-agonists, and in some cases may exacerbate bronchospasm in patients with reactive airways. -Hypersensitivity to atropine and its derivatives (Minor) Beta-agonists may be associated with adverse cardiovascular effects including QT interval prolongation, usually at higher doses and/or when associated with hypokalemia. For acute asthma exacerbations, NAEPP recommends 2.5 to 5 mg every 20 minutes for 3 doses, then 2.5 to 10 mg every 1 to 4 hours as needed or 10 to 15 mg/hour by continuous nebulization. Beta-agonists may rarely be associated with adverse cardiovascular effects including QT interval prolongation, usually at higher doses and/or when associated with hypokalemia. [43674] Other products state that the vials should be stored in the foil pouch until time of use. Sevoflurane: (Minor) Sevoflurane, like other halogenated anesthetics, can prolong the QT interval. Monitoring of potassium levels would be advisable. Monoamine oxidase inhibitors: (Major) Beta-agonists should be administered with extreme caution to patients being treated with monoamine oxidase inhibitors (MAOIs) due to their sympathomimetic effects. [49951] Other products should be discarded when the labeled number of actuations has been used or by the expiration date printed on original packaging; whichever comes first. Romidepsin: (Minor) Romidepsin has been reported to prolong the QT interval. Monitor the patients lung and cardiovascular status closely. Beta-agonists may be associated with adverse cardiovascular effects including QT interval prolongation, usually at higher doses and/or when associated with hypokalemia. Concurrent use may increase the effects of sympathomimetics or thyroid hormone. For acute asthma exacerbations, the National Asthma Education and Prevention Program (NAEPP) Expert Panel recommends 4 to 8 puffs every 20 minutes for 3 doses, then 4 to 8 puffs every 1 to 4 hours as needed. Beta-agonists may be associated with adverse cardiovascular effects including QT interval prolongation, usually at higher doses, when associated with hypokalemia, or when used with other drugs known to prolong the QT interval. After the first hour, the dose required may vary from 4 to 10 puffs every 3 to 4 hours up to 6 to 10 puffs every 1 to 2 hours, or more often. Beta-agonists may be associated with adverse cardiovascular effects including QT interval prolongation, usually at higher doses, when associated with hypokalemia, or when used with other drugs known to prolong the QT interval. Articaine; Epinephrine: (Moderate) Caution and close observation should be used when albuterol is used concurrently with other adrenergic sympathomimetics, administered by any route, to avoid potential for increased cardiovascular effects. Nebulizer solution: 3 mL inhaled q6hr; not to exceed 3 mL q4hr. Albuterol belongs to the family of medicines known as adrenergic bronchodilators. Postmarketing data indicate that hydroxyzine causes QT prolongation and TdP. Monitoring of potassium levels would be advisable. While significantly less common, weight-based dosing of 0.05 to 0.1 mg/kg/dose was also reported by some centers as their usual dose. Doses were repeated every 2 hours until serum potassium concentrations fell to less than 5 mmol/L, the patient experienced adverse effects, or the maximum of 12 doses was reached. Drugs with a possible risk for QT prolongation that should be used cautiously and with close monitoring with quetiapine include the beta-agonists. Beta-agonists inhibit the airway response to methacholine. A cardiovascular examination, including an ECG, should be obtained in all patients prior to initiating anagrelide therapy. Beta-agonists may be associated with adverse cardiovascular effects including QT interval prolongation, usually at higher doses, when associated with hypokalemia, or when used with other drugs known to prolong the QT interval. Beta-agonists may be associated with adverse cardiovascular effects including QT interval prolongation, usually at higher doses, when associated with hypokalemia, or when used with other drugs known to prolong the QT interval. This risk may be more clinically significant with long-acting beta-agonists as compared to short-acting beta-agonists. This risk may be more clinically significant with long-acting beta-agonists as compared to short-acting beta-agonists. Hypokalemia due to beta agonists appears to be dose related and is more likely with high dose therapy. After oral administration, 75% of a dose is excreted in urine within 72 hours as metabolites; 4% may be found in feces. Max: 32 mg/day PO. Albuterol is preferred over other SABAs due to extensive safety-related information during pregnancy. Monitor the patients lung and cardiovascular status closely. If adequate response not obtained, dose may be increased gradually with caution. Caffeine; Ergotamine: (Moderate) Sensitive patients may wish to limit or avoid excessive caffeine intake from foods, beverages, dietary supplements and medications during therapy with beta-agonists. Sensitive patients might experience tremor, sleep difficulties, or mild increases in heart rate. This risk may be more clinically significant with long-acting beta-agonists (i.e., formoterol, arformoterol, indacaterol, olodaterol, salmeterol, umeclidinium; vilanterol) than with short-acting beta-agonists. Use the dropper supplied by the manufacturer to carefully measure the prescribed amount of medication and place in the nebulizer with sterile saline as directed. In a survey of 68 academic medical center neonatal intensive care units (NICUs), 95% reported 1 to 2 puffs as the average dose used. By nebulizer: 2.5mg (0.5mL of 0.5% diluted to 3mL with sterile normal saline, or 3mL of 0.083%) 3–4 times daily. In December 2001, the FDA issued a black box warning regarding the use of droperidol and its association with QT prolongation and potential for cardiac arrhythmias based on post-marketing surveillance data. This risk may be more clinically significant with long-acting beta-agonists as compared to short-acting beta-agonists. Albuterol is made use of for preventing or relieving bronchospasm in patients dealing with exercise-induced asthma or asthma created by other problems. Beta-agonists and beta-blockers are pharmacologic opposites, and will counteract each other to some extent when given concomitantly, especially when non-cardioselective beta blockers are used. This risk may be more clinically significant with long-acting beta-agonists as compared to short-acting beta-agonists. The cardiovascular effects of beta-agonists may be potentiated by concomitant use of MAOIs. Consult a cardiologist regarding appropriate monitoring if siponimod use is required. Put the cap back on the mouthpiece after use.Following administration, instruct patient to rinse the mouth with water to minimize dry mouth.To avoid the spread of infection, do not use the inhaler for more than one person.Clean the plastic mouthpiece of the inhaler at least once a week; some manufacturers advocate daily cleaning. Solifenacin: (Minor) Solifenacin has been associated dose-dependent prolongation of the QT interval. Initially, 2 mg PO 3 to 4 times per day. Desipramine: (Minor) Tricyclic antidepressants (TCAs) share pharmacologic properties similar to the Class IA antiarrhythmic agents and may prolong the QT interval, particularly in overdose or with higher-dose prescription therapy (elevated serum concentrations). Liothyronine: (Moderate) Based on the cardiovascular stimulatory effects of beta-agonists and other sympathomimetics, concomitant use with thyroid hormones might enhance the effects on the cardiovascular system. 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